01 / DIRECT GLUCURONIDATION
Clean Metabolic Pathway
Lorazepam undergoes direct Phase II glucuronidation without active metabolites, ensuring predictable clearance and minimal risk of hepatic metabolite accumulation.
Blessme · Anxiolytics & Sedatives
Lorazepam Tablets IP 1 mg - LORZIN-1
LORZIN-1 is a high-purity oral formulation containing Lorazepam IP 1 mg by Blessme, Dellwich Lifescience LLP. An intermediate-acting benzodiazepine engineered for the rapid suppression of acute anxiety, panic attacks, psychosomatic tension, and short-term anxiety-associated insomnia, providing predictable GABAergic limbic calming with direct glucuronidation metabolism.
Direct Glucuronidation
Narcotic / Schedule H
Pan-India Supply
Product SpecificationsAbout Lorazepam Tablets IP 1 mg
About Lorazepam Tablets IP 1 mg
(LORZIN-1)
Comprehensive pharmaceutical specifications, active API monograph compliance, pharmacokinetic profiles, and 4x5x10 blister packaging details for LORZIN-1.
Blessme · Anxiolytic & Sedative
Lorazepam Tablets IP 1 mg - LORZIN-1
LORZIN-1 delivers precise 1 mg Lorazepam per compressed tablet. Recommended as a cornerstone starting and maintenance anxiolytic for acute anxiety states, panic disorder, and transient sleep disruption without active metabolite burden.
1 mg Lorazepam Delivers Prompt Limbic & Amygdala Suppression Direct Phase II Glucuronidation (No Active Metabolites) Intermediate Half-Life (10-20 Hours) Prevents Prolonged Hangover 4x5x10 Blister Strip Format for Tropical Protection Strict Indian Pharmacopoeia Quality Standards
- Product Brand Name
- LORZIN-1
- Active Pharmaceutical Ingredient
- Lorazepam IP 1 mgVerified IP
- Therapeutic Class
- Neuropsychiatric Anxiolytic & Sedative (Benzodiazepine)
- Dosage Form
- Oral Solid Compressed Tablet
- Strength Formulation
- 1 mg Lorazepam
- Packaging Standard
- 4x5x10 Blister Strips (200 Tablets per Box)
- Regulatory Category
- Narcotic Drug
- Marketing Division
- Blessme · Neuro & Psychiatric Products
- Manufacturing Standard
- WHO-GMP & ISO 9001:2015 Certified Clean-Room Compression
- Storage Condition
- Store below 25°C in a dry place. Protect from light and moisture.
- Country of Origin
- India
Clinical & Commercial MonographLorazepam Tablet 1 mg & LORZIN-1
Lorazepam Tablet 1 mg & LORZIN-1
Complete Medical & Supply Guide
In-depth pharmacological evaluation of Lorazepam 1 mg tablets, marketed as LORZIN-1 by Blessme (Dellwich Lifescience LLP). Covers GABAergic receptor mechanisms, clinical advantages of direct glucuronidation, and pharmaceutical franchise availability across India.
What is LORZIN-1 (Lorazepam 1 mg)?
LORZIN-1 is a high-potency oral benzodiazepine tablet formulated with 1 mg of pure Lorazepam IP. Clinically categorized as an intermediate-acting anxiolytic, sedative, and anticonvulsant agent, Lorazepam is widely prescribed worldwide for its rapid onset and clean metabolic profile.
In acute psychiatric emergencies and generalized anxiety episodes, LORZIN-1 quickly attenuates hyperactive autonomic reflexes, terminating palpitations, trembling, and overwhelming psychic dread within 30 to 60 minutes of oral administration.
Clinical Uses & Evidence-Based Indications
Approved neurological and psychiatric indications for LORZIN-1 include:
- Generalized Anxiety Disorder (GAD): Fast relief of psychic tension and excessive apprehension.
- Acute Panic Episodes: Halts acute panic attacks and reduces autonomic panic hyperarousal.
- Short-Term Insomnia: Facilitates restorative sleep in patients suffering from anxiety-induced sleeplessness.
- Preoperative Anxiolysis & Sedation: Provides pre-anesthetic calming and mild anterograde amnesia.
- Adjunctive Psychomotor Agitation: Stabilizes acute agitation and manic restlessness under medical supervision.
Neurochemical Mechanism of Action: GABAA Receptor Positive Modulation
Lorazepam binds stereospecifically to the benzodiazepine receptor site located at the interface between the alpha and gamma subunits of the pentameric GABAA receptor-chloride ionophore complex in the brain.
This binding causes an allosteric conformational shift that increases receptor affinity for the inhibitory neurotransmitter gamma-aminobutyric acid (GABA). The resulting increased frequency of chloride channel opening leads to cellular hyperpolarization, which powerfully dampens neuronal firing throughout the limbic system, thalamus, and motor cortex.
The Hepatic Advantage: Lorazepam vs. Other Benzodiazepines
Why clinicians consistently prefer Lorazepam for patients with hepatic or metabolic considerations:
- Direct Glucuronidation: Lorazepam does not undergo CYP450 phase I oxidation. It is directly conjugated into inactive lorazepam-glucuronide.
- No Active Metabolites: Elimination is linear with no lingering active intermediate products like desmethyldiazepam.
- Predictable Clearance: Safer in geriatric patients and those with mild hepatic impairment compared to long-acting agents.
Dosage Guidelines & Administration Method
LORZIN-1 must be taken strictly in accordance with medical advice:
- Initial Anxiety Dose: Usually 1 mg taken 2 to 3 times daily, adjusted according to severity and response.
- Insomnia Dose: 1 to 2 mg taken at bedtime with water.
- Elderly or Debilitated Patients: Recommended starting dose of 0.5 mg to 1 mg daily in divided doses.
- Duration & Tapering: Prescribed for short durations (2-4 weeks); discontinue gradually under psychiatric supervision.
Critical Safety Warning - Schedule H / Narcotic Controlled Substance
LORZIN-1 contains Lorazepam, which carries potential for dependence and habit formation with prolonged therapy. Do not consume alcohol during therapy. Not recommended during pregnancy. Dispensed strictly against a valid registered medical prescription.
Quality & Production
Pharmaceutical Quality Assurance & Compliance
LORZIN-1 is manufactured in WHO-GMP certified facilities adhering to Schedule M protocols, ensuring micro-blend homogeneity, exact active content, and superior packaging stability.
02 / PROTECTIVE PACKAGING
High-Barrier 4x5x10 Blister
Tropicalized 4x5x10 blister packaging protects sensitive active APIs against atmospheric humidity and oxidation, ensuring 36-month stability across all Indian zones.
03 / PHARMACOPOEIA DOSSIERS
COA & Batch Testing Records
Every batch is verified through authenticated Certificates of Analysis (COA), HPLC active assay validation, and dissolution profiles adhering strictly to IP standards.
04 / WHO-GMP COMPLIANCE
Schedule M Manufacturing
Manufactured in accredited cleanroom units in Gujarat adhering to automated compression, online check-weighing, and Good Laboratory Practices (GLP).
Clinical Profile & Precautions
Approved Indications & Regulatory Guidelines
Prescribing guidance, contraindications, and drug interactions for Lorazepam 1 mg tablets.
Prescription-Only Schedule H / Narcotic Medication Notice
LORZIN-1 is a Schedule H / Narcotic prescription drug. Not for OTC sale. Do not consume alcohol during therapy. Exercise caution when driving or operating machinery.
Clinical Indications Profile
Approved neurological and psychiatric indications for LORZIN-1:
- Acute Anxiety & Panic States: Rapid symptomatic control over psychic tension and palpitations.
- Anxiety-Related Insomnia: Promotes natural sleep onset with low risk of next-day morning grogginess.
- Pre-Anesthetic Sedation: Calms apprehension and provides light anterograde amnesia prior to procedures.
- Alcohol Withdrawal Agitation: Manages acute tremor, autonomic hyperactivity, and agitation.
Contraindications & Precautions
Key contraindications and monitoring requirements:
- Severe Respiratory Insufficiency: Contraindicated in severe respiratory depression or sleep apnea.
- Myasthenia Gravis: Use with extreme caution due to intrinsic muscle relaxant properties.
- Alcohol Prohibition: Concurrent alcohol consumption precipitates dangerous additive CNS depression.
- Gradual Discontinuation: Taper slowly under physician direction to prevent rebound anxiety.
Manufacturing & Marketing
Dellwich Lifescience LLPBlessme · Neuro & Psychiatric Division
About Dellwich Lifescience
Trusted Neuro & Psychiatric Pharmaceutical Manufacturer in Ahmedabad, Gujarat
Dellwich Lifescience LLP is an established pharmaceutical company based in Science City, Ahmedabad, Gujarat, dedicated to advanced formulation technology, uncompromising quality assurance, and ethical healthcare supply. Through our specialized neurology division, Blessme, we manufacture and market superior neuro-psychiatric treatments, including LORZIN-1 (Lorazepam Tablets IP 1 mg).
We support PCD pharma franchise partners, hospital supply chains, and contract manufacturing clients across India with guaranteed supply security, validated product dossiers, and prompt dispatch.
Commercial PartnershipsLORZIN-1 Supply &
LORZIN-1 Supply &
Pharmaceutical Distribution
Whether you are seeking LORZIN-1 for district monopoly PCD franchise distribution, third-party contract manufacturing, or hospital bulk procurement, Dellwich Lifescience LLP delivers dependable supply and competitive trade margins.
Exclusive Monopoly PCD Franchise
Secure district-level monopoly marketing rights for LORZIN-1 and the Blessme neuropsychiatry portfolio with visual aids, product glossaries, and promotional input support.
Third-Party Contract Manufacturing
Turnkey manufacturing solutions for pharmaceutical marketing companies with flexible batch runs, rapid production turnaround, and full regulatory dossier support from Ahmedabad.
Hospital & Institutional Procurement
Direct bulk pharmaceutical supply agreements for multispecialty hospital chains, psychiatric nursing homes, and institutional medical tenders with prompt pan-India logistics.
Blessme · LORZIN-1
Why Choose LORZIN-1 Tablets?
When sourcing Lorazepam 1 mg tablets in India, LORZIN-1 by Blessme provides exceptional clinical efficacy, reliable blister packaging, and comprehensive B2B franchise support.
WHO-GMP Certified Purity
Manufactured in accredited facilities using IP grade active APIs, ensuring exact content uniformity and fast dissolution.
High-Barrier Blister Packaging
Tamper-evident, moisture-resistant blister strips protect tablets from ambient humidity and transport friction.
Pan-India Dispatch from Ahmedabad
Direct factory dispatch with GST invoicing, verified batch COA, and dependable logistics coverage across all Indian states.
Monopoly PCD Franchise Rights
Exclusive district-level franchise rights for LORZIN-1 and the Blessme portfolio with promotional visual aids.
Comprehensive Regulatory Dossiers
Certificates of Analysis (COA), stability testing data, and MSDS readily available for institutional audits and tenders.
Direct Manufacturer Support
Direct access to Dellwich Lifescience product specialists for quick quotes, customized bulk orders, and customer assistance.
Common Questions
Frequently Asked Questions about LORZIN-1
Authoritative answers to clinical, commercial, dosage, and regulatory questions regarding Lorazepam 1 mg tablets.
What is LORZIN-1 and what does it contain?
LORZIN-1 is an oral prescription tablet from the Blessme division of Dellwich Lifescience. It contains Lorazepam IP 1 mg, formulated for rapid tranquilization, acute anxiety suppression, and short-term relief of anxiety-induced insomnia.
How does Lorazepam 1 mg work?
Lorazepam enhances the action of gamma-aminobutyric acid (GABA), the major inhibitory neurotransmitter in the brain, by binding to GABA_A receptors. This increases inhibitory chloride conductance, calming neuronal hyperactivity and alleviating emotional tension and physical trembling.
What conditions are treated with LORZIN-1?
LORZIN-1 is prescribed for acute anxiety states, Generalized Anxiety Disorder (GAD), acute panic crises, anxiety-associated insomnia, pre-anesthetic sedation, and acute psychomotor agitation.
How fast does LORZIN-1 take effect?
Lorazepam is absorbed rapidly following oral administration, with peak plasma concentrations reached in approximately 1.5 to 2 hours. Clinical anxiety relief is typically observed within 30 to 60 minutes.
What makes Lorazepam different from Diazepam or Alprazolam?
Lorazepam has an intermediate elimination half-life (10 to 20 hours) and is metabolized solely by Phase II glucuronidation into an inactive glucuronide conjugate. Unlike Diazepam, it does not form long-lived active metabolites (like desmethyldiazepam), reducing risk of drug accumulation in the elderly or mild hepatic impairment.
Can LORZIN-1 cause daytime drowsiness?
Yes. As a central nervous system depressant, Lorazepam can induce sedation, lightheadedness, and reduced reaction time. Patients should avoid operating motor vehicles or dangerous machinery until individual response is determined.
Can LORZIN-1 be taken with alcohol?
Alcohol is strictly contraindicated. Concurrent use of alcohol with Lorazepam potentiates severe CNS depression, potentially causing extreme sedation, severe respiratory depression, and coma.
Is LORZIN-1 habit-forming?
Yes. Like all benzodiazepines, Lorazepam carries risk of tolerance and psychological or physical dependence with extended use. It is typically prescribed for short durations (2 to 4 weeks) and should never be stopped abruptly.
How should LORZIN-1 be discontinued?
Treatment should never be stopped abruptly. Clinicians implement a structured step-down dose tapering schedule to prevent withdrawal symptoms such as rebound insomnia, autonomic agitation, and sensory hyperacusis.
Can pregnant women take LORZIN-1?
Lorazepam is contraindicated during pregnancy, especially during the first and third trimesters, as benzodiazepines can increase the risk of congenital abnormalities, neonatal hypotonia ('floppy infant syndrome'), and respiratory depression.
How is LORZIN-1 packaged?
LORZIN-1 is supplied in 4x5x10 blister strips (200 tablets per box) manufactured with tropicalized barrier foil to guarantee shelf stability across all regional climate conditions in India.
How can distributors apply for PCD franchise monopoly for LORZIN-1?
Pharmaceutical distributors and stockists can submit an enquiry through our online form below or contact our neuropsychiatry franchise desk at +91 99099 31992 for monopoly territory allocation.
Does Dellwich Lifescience offer third-party contract manufacturing for Lorazepam tablets?
Yes. Dellwich Lifescience provides turnkey contract manufacturing for Lorazepam oral solid dosage forms with WHO-GMP certification, validated analytical dossiers, and rapid batch dispatch.
Where is Dellwich Lifescience headquartered?
Dellwich Lifescience LLP is headquartered on Science City Road, Ahmedabad, Gujarat, India, with rapid logistics connections across all Indian states.
Direct Pharmaceutical Enquiry
Need Verified Information or Bulk Supply of LORZIN-1?
Connect directly with Dellwich Lifescience LLP for trade pricing, district monopoly PCD rights, third-party manufacturing, or institutional hospital tender supplies.
Direct Manufacturer Pricing & Transparent MOQ
Exclusive PCD Monopoly Rights for Designated Districts
Fast Dispatch from Ahmedabad with GST Invoicing
Comprehensive Marketing, Visual Aids & Promotional Inputs
Quick Assistance & Orders
Enquire About LORZIN-1
Get wholesale pricing, PCD franchise monopoly rights, and technical documentation for Lorazepam 1 mg Tablets.