01 / CHRONOBIOTIC-GABA ASSAY
Dual Active Release Uniformity
Each tablet contains Clonazepam 0.5 mg and Melatonin 5 mg with precision content uniformity and consistent dissolution kinetics complying with Indian Pharmacopoeia standards.
Blessme · Sleep Architecture & Anxiolytics
Clonazepam + Melatonin Tablets - DELOTRIL-PLUS-5
DELOTRIL-PLUS-5 is an innovative dual-action neuro-hypnotic tablet combining Clonazepam IP 0.5 mg with Melatonin 5 mg by Blessme, Dellwich Lifescience LLP. Formulated to restore natural sleep architecture in patients suffering from anxiety-induced insomnia, delayed sleep phase syndrome, and nocturnal panic attacks without suppressing physiological deep sleep stages.
Circadian + GABA Synergy
Schedule H Prescription
Pan-India Supply
Product SpecificationsAbout Clonazepam + Melatonin
About Clonazepam + Melatonin
(DELOTRIL-PLUS-5)
Detailed pharmaceutical specifications, active API monograph compliance, circadian sleep architecture restoration, and blister packaging details for DELOTRIL-PLUS-5.
Blessme · Sleep Architecture & Anxiolytic
Clonazepam + Melatonin - DELOTRIL-PLUS-5
DELOTRIL-PLUS-5 pairs 5 mg of the physiological sleep hormone Melatonin with 0.5 mg of the high-potency anxiolytic Clonazepam. It delivers physiological sleep onset while calming nocturnal anxiety and autonomic arousal.
5 mg Melatonin Activates SCN MT1 & MT2 Sleep Receptors0.5 mg Clonazepam Silences Nocturnal Panic & Racing ThoughtsRestores Deep Slow-Wave & REM Sleep StagesPhotolytic & Moisture Barrier Blister Foil Strips Strict Indian Pharmacopoeia Quality Standards
- Product Brand Name
- DELOTRIL-PLUS-5
- Active Pharmaceutical Ingredients
- Clonazepam IP 0.5 mg + Melatonin 5 mgVerified IP
- Therapeutic Class
- Hypnotic / Chronobiotic & Anxiolytic Combination
- Dosage Form
- Oral Solid Compressed Tablet
- Strength Formulation
- 0.5 mg Clonazepam + 5 mg Melatonin (Sleep Architecture Formula)
- Packaging Standard
- 10x10 Moisture-Resistant Blister Strips
- Regulatory Category
- Narcotic Drug
- Marketing Division
- Blessme · Neuro & Psychiatric Products
- Manufacturing Standard
- WHO-GMP & ISO 9001:2015 Certified Clean-Room Compression
- Storage Condition
- Store below 25°C in a dry place. Protect from light and moisture.
- Country of Origin
- India
Clinical & Commercial MonographClonazepam + Melatonin Tablet & DELOTRIL-PLUS-5
Clonazepam + Melatonin Tablet & DELOTRIL-PLUS-5
Complete Medical & Supply Guide
In-depth pharmacological evaluation of Clonazepam IP 0.5 mg + Melatonin 5 mg tablets, marketed as DELOTRIL-PLUS-5 by Blessme (Dellwich Lifescience LLP). Covers circadian rhythm pharmacology, sleep architecture restoration, and pharmaceutical supply across India.
What is DELOTRIL-PLUS-5 (Clonazepam 0.5 mg + Melatonin 5 mg)?
DELOTRIL-PLUS-5 is an advanced sleep-regulating tablet combining a circadian chronobiotic agent with an inhibitory GABAergic anxiolytic. In patients with severe anxiety, elevated nocturnal sympathetic tone and hypercortisolemia suppress pineal melatonin secretion, producing intractable sleep initiation insomnia.
When somnologists and psychiatrists search for Clonazepam Melatonin tablet or medicine for anxiety-induced insomnia and nocturnal panic, they look for dual-target formulations that do not distort natural REM and slow-wave sleep. DELOTRIL-PLUS-5 meets these rigorous requirements through automated clean-room manufacturing under WHO-GMP compliance.
Clinical Uses & Evidence-Based Indications
Approved neurological and psychiatric indications for DELOTRIL-PLUS-5 include:
- Severe Chronic Insomnia with Anxiety: Accelerated sleep initiation and continuous sleep maintenance without middle-of-the-night awakening.
- Nocturnal Panic Attacks: Abrupt night-time awakenings accompanied by gasping, palpitations, and terror.
- Delayed Sleep Phase Syndrome (DSPS): Inability to fall asleep until early morning due to circadian dysregulation.
- Shift-Work Sleep Disorder: Disrupted sleep architecture resulting from rotational night shifts.
- Post-Traumatic Night-Time Agitation: Reduces nocturnal hypervigilance, bruxism, and restless motor arousal.
Neurochemical Mechanism of Action: Chronobiotic & GABAergic Synergy
Melatonin 5 mg acts as a high-affinity agonist at MT1 and MT2 G-protein coupled receptors located in the suprachiasmatic nucleus (SCN) of the anterior hypothalamus. MT1 receptor activation attenuates SCN neuronal firing, promoting hypothermia and initiating the physiological sleep cascade, while MT2 activation facilitates circadian phase shifting.
Concurrently, Clonazepam 0.5 mg binds stereospecifically to GABAA receptor complexes in the thalamic reticular nucleus and limbic system. By potentiating chloride channel conductance, it stabilizes cortical hyperarousal, quiets racing thoughts, and suppresses nocturnal panic awakenings. Together, they restore peaceful, restorative sleep architecture throughout the night.
Formulation Advantage: DELOTRIL-PLUS-5 vs. Conventional Hypnotics
Clinical benefits of DELOTRIL-PLUS-5 over classical Z-drugs and sedatives:
- Circadian Alignment: Melatonin resets the biological master clock rather than merely forcing heavy chemical sedation.
- Anxiety Suppression: Clonazepam eliminates the anticipatory bed-time anxiety that causes sleep dread.
- Sleep Quality Preservation: Protects deep stage-3/4 NREM restorative sleep and physiologic REM cycles.
- Nocturnal Panic Shield: Long half-life of Clonazepam prevents mid-sleep autonomic panic surges.
Dosage Guidelines & Administration Method
DELOTRIL-PLUS-5 must be taken strictly in accordance with medical advice:
- Administration Time: Take one tablet 30 to 60 minutes before bedtime with water.
- Dedicated Sleep Duration: Ensure a dedicated 7 to 8-hour window for uninterrupted nocturnal sleep.
- Avoid Light Exposure: Minimize smartphone/screen blue light exposure after taking the tablet.
- Gradual Tapering: Discontinue gradually under psychiatric direction to prevent rebound insomnia.
Critical Safety Warning - Schedule H Controlled Psychotropic Substance
DELOTRIL-PLUS-5 contains Clonazepam, which carries potential for tolerance and habit formation with prolonged therapy. Strictly avoid alcohol or concurrent CNS depressant medications. Dispensed strictly against a valid medical prescription.
Quality & Production
Pharmaceutical Quality Assurance & Compliance
DELOTRIL-PLUS-5 is manufactured in WHO-GMP certified facilities adhering to Schedule M protocols, ensuring micro-blend homogeneity and maximum packaging stability.
02 / PROTECTIVE PACKAGING
Photolytic & Moisture Barrier Foil
Sealed in high-barrier blister strips specially coated to protect photosensitive Melatonin and hygroscopic excipients from environmental breakdown across tropical conditions.
03 / PHARMACOPOEIA DOSSIERS
COA & Batch Testing Records
Every batch is backed by authenticated Certificates of Analysis (COA), disintegration profiles, assay validation data, and Material Safety Data Sheets for hospital audits.
04 / WHO-GMP COMPLIANCE
Schedule M Manufacturing
Produced in state-of-the-art accredited manufacturing units in Gujarat adhering to automated compression, online check-weighing, and Good Laboratory Practices (GLP).
Clinical Profile & Precautions
Approved Indications & Regulatory Guidelines
Prescribing guidance, contraindications, and drug interactions for Clonazepam 0.5 mg + Melatonin 5 mg tablets.
Prescription-Only Schedule H Medication Notice
DELOTRIL-PLUS-5 is a Schedule H prescription drug. Not for OTC sale. Do not consume alcohol during therapy. Exercise caution when driving or operating machinery the following morning.
Clinical Indications Profile
Approved neurological and psychiatric indications for DELOTRIL-PLUS-5:
- Insomnia Comorbid with Anxiety: Restores circadian onset and prevents sleep interruption.
- Nocturnal Panic Disorder: Abrupt middle-of-night awakenings with tachycardia.
- Delayed Sleep Phase Disorder: Circadian phase normalization.
- Shift-Work Sleep Disturbance: Sleep architecture synchronization.
Contraindications & Precautions
Key contraindications and monitoring requirements:
- Respiratory Depression: Contraindicated in severe sleep apnea and respiratory failure.
- Alcohol Prohibition: Potentiates severe CNS depression and respiratory risk.
- Hepatic Impairment: Dose reduction required in significant hepatic dysfunction.
- Pregnancy & Lactation: Avoid use unless explicitly advised by a specialist.
Manufacturing & Marketing
Dellwich Lifescience LLPBlessme · Neuro & Psychiatric Division
About Dellwich Lifescience
Trusted Neuro & Psychiatric Pharmaceutical Manufacturer in Ahmedabad, Gujarat
Dellwich Lifescience LLP is an established pharmaceutical company based in Science City, Ahmedabad, Gujarat, dedicated to advanced formulation technology, uncompromising quality assurance, and ethical healthcare supply. Through our specialized neurology division, Blessme, we manufacture and market superior neuro-psychiatric treatments, including DELOTRIL-PLUS-5 (Clonazepam 0.5 mg + Melatonin 5 mg Tablets).
We support PCD pharma franchise partners, hospital supply chains, and contract manufacturing clients across India with guaranteed supply security, validated product dossiers, and prompt dispatch.
Commercial PartnershipsDELOTRIL-PLUS-5 Supply &
DELOTRIL-PLUS-5 Supply &
Pharmaceutical Distribution
Whether you are seeking DELOTRIL-PLUS-5 for district monopoly PCD franchise distribution, third-party contract manufacturing, or hospital bulk procurement, Dellwich Lifescience LLP delivers dependable supply and competitive trade margins.
Exclusive Monopoly PCD Franchise
Secure district-level monopoly marketing rights for DELOTRIL-PLUS-5 and the Blessme neuropsychiatry range with visual aids, product glossaries, and promotional input support.
Third-Party Contract Manufacturing
Turnkey manufacturing solutions for pharmaceutical marketing companies with flexible batch runs, rapid production turnaround, and full regulatory dossier support from Ahmedabad.
Hospital & Institutional Procurement
Direct bulk pharmaceutical supply agreements for multispecialty hospital chains, psychiatric nursing homes, and institutional medical tenders with prompt pan-India logistics.
Blessme · DELOTRIL-PLUS-5
Why Choose DELOTRIL-PLUS-5 Tablets?
When sourcing Clonazepam Melatonin tablets in India, DELOTRIL-PLUS-5 by Blessme provides exceptional clinical efficacy, reliable blister packaging, and comprehensive B2B franchise support.
WHO-GMP Certified Purity
Manufactured in accredited facilities using IP grade APIs, ensuring exact active content uniformity and fast disintegration.
High-Barrier Blister Packaging
Tamper-evident, moisture-resistant blister strips protect tablets from ambient humidity and light degradation.
Pan-India Dispatch from Ahmedabad
Direct factory dispatch with GST invoicing, verified batch COA, and dependable logistics coverage across all Indian states.
Monopoly PCD Franchise Rights
Exclusive district-level franchise rights for DELOTRIL-PLUS-5 and the Blessme portfolio with promotional visual aids.
Comprehensive Regulatory Dossiers
Certificates of Analysis (COA), stability testing data, and MSDS readily available for institutional audits and tenders.
Direct Manufacturer Support
Direct access to Dellwich Lifescience product specialists for quick quotes, customized bulk orders, and customer assistance.
Common Questions
Frequently Asked Questions about DELOTRIL-PLUS-5
Authoritative answers to clinical, commercial, dosage, and regulatory questions regarding Clonazepam + Melatonin tablets.
What is DELOTRIL-PLUS-5 and what does it contain?
DELOTRIL-PLUS-5 is an oral prescription tablet from the Blessme division of Dellwich Lifescience. It combines Clonazepam IP 0.5 mg (a potent anxiolytic benzodiazepine) with Melatonin 5 mg (a natural chronobiotic hormone), specifically engineered to treat sleep disturbances comorbid with severe anxiety.
How is DELOTRIL-PLUS-5 different from standard sleeping pills?
Standard sedative hypnotics (such as Zolpidem or Zopiclone) solely induce sedation without addressing underlying anxiety or circadian rhythm disruption. DELOTRIL-PLUS-5 restores the physiological circadian signal via Melatonin while simultaneously relieving anxiety and muscle tension via Clonazepam, leading to higher sleep quality.
When should DELOTRIL-PLUS-5 be taken?
DELOTRIL-PLUS-5 should be taken once daily at bedtime, approximately 30 to 60 minutes before intending to sleep, strictly as prescribed by a qualified physician.
Does this medication cause next-day drowsiness?
Melatonin is cleared rapidly from the body and does not cause residual grogginess. However, Clonazepam has an elimination half-life of 30 to 40 hours. In initial days of therapy, some patients may experience mild daytime drowsiness. Patients should ensure at least 7 to 8 hours of dedicated sleep time.
Is DELOTRIL-PLUS-5 habit-forming?
Melatonin carries zero dependence risk. However, Clonazepam has potential for tolerance and dependence with long-term continuous use. For this reason, DELOTRIL-PLUS-5 is recommended for short-to-medium term therapy under physician supervision.
How should DELOTRIL-PLUS-5 be discontinued?
Following extended continuous usage, treatment should be tapered gradually under medical direction rather than abruptly discontinued, to avoid rebound insomnia and withdrawal anxiety.
Can I consume alcohol while taking DELOTRIL-PLUS-5?
No. Alcohol interacts dangerously with Clonazepam, intensifying central nervous system depression, leading to severe drowsiness, respiratory suppression, and impaired coordination.
Is DELOTRIL-PLUS-5 suitable for elderly patients?
Elderly patients are more sensitive to benzodiazepines and have higher risks of nocturnal ataxia, confusion, and falls. In elderly individuals, doctors typically start with lower initial doses or evaluate risk-benefit carefully.
Can this tablet help with jet lag or shift work?
Yes. Under medical supervision, DELOTRIL-PLUS-5 can help reset disrupted circadian rhythms while reducing travel-induced anxiety and insomnia.
What packaging format is used for DELOTRIL-PLUS-5?
DELOTRIL-PLUS-5 is packed in 10x10 blister strips manufactured with high-barrier protective foils to prevent photolytic and moisture breakdown of Melatonin and Clonazepam.
How does DELOTRIL-PLUS-5 compare with DELOTRIL-PRO-0.5?
DELOTRIL-PLUS-5 combines Clonazepam with Melatonin for bedtime use to treat sleep architecture disorders and nighttime panic. DELOTRIL-PRO-0.5 combines Clonazepam with Propranolol (a beta-blocker) for daytime somatic panic attacks and palpitations.
How do I get PCD monopoly franchise rights for this product?
Interested distributors can submit an enquiry via the form below or message our franchise support team on WhatsApp at +91 99099 31992 for territory availability and price quotations.
Can Dellwich manufacture this tablet under third-party contract?
Yes. Dellwich Lifescience provides end-to-end third-party manufacturing for Clonazepam + Melatonin tablets with customized branding, regulatory dossiers, and prompt batch deliveries.
Where is Dellwich Lifescience located?
Dellwich Lifescience LLP is headquartered on Science City Road, Ahmedabad, Gujarat, India, with delivery operations spanning pan-India healthcare networks.
Direct Pharmaceutical Enquiry
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