01 / DUAL ACTIVE ASSAY
Validated Micro-Dose Blending
Each tablet delivers Clonazepam 0.25 mg and Propranolol 10 mg with precision content uniformity and consistent dissolution kinetics complying with Indian Pharmacopoeia standards.
Blessme · Anti-Panic & Somatic Anxiolytics
Clonazepam + Propranolol Tablets - DELOTRIL-PRO-LS
DELOTRIL-PRO-LS is a precision low-strength oral tablet combining Clonazepam IP 0.25 mg with Propranolol Hydrochloride IP 10 mg by Blessme, the dedicated neuro-psychiatric division of Dellwich Lifescience LLP. Specifically formulated to break the psycho-somatic anxiety loop by arresting central fear signaling in the amygdala while eliminating peripheral cardiac palpitations, tremors, and diaphoresis without heavy daytime sedation.
Dual Action Synergy
Schedule H Prescription
Pan-India Supply
Product SpecificationsAbout Clonazepam + Propranolol
About Clonazepam + Propranolol
(DELOTRIL-PRO-LS)
Detailed pharmaceutical specifications, active API monograph compliance, low-strength somatic synergy, and blister packaging details for DELOTRIL-PRO-LS.
Blessme · Somatic Anxiolytic & Beta Blocker
Clonazepam + Propranolol - DELOTRIL-PRO-LS
DELOTRIL-PRO-LS unites micro-dose Clonazepam (0.25 mg) with low-dose Propranolol (10 mg) to offer an ideal first-line option for patients suffering from somatic anxiety manifestations, public speaking phobias, stage fright, and mild-to-moderate panic attacks.
Dual Central GABA_A + Peripheral Beta-Blockade Low 0.25 mg Clonazepam Minimizes Sedation10 mg Propranolol Gently Arrests Palpitations & Tremors High-Barrier Moisture-Proof Blister Packing Strict Indian Pharmacopoeia Quality Standards
- Product Brand Name
- DELOTRIL-PRO-LS
- Active Pharmaceutical Ingredients
- Clonazepam IP 0.25 mg + Propranolol HCl IP 10 mgVerified IP
- Therapeutic Class
- Neuropsychiatric Anxiolytic & Beta-Adrenergic Blocker
- Dosage Form
- Oral Solid Compressed Tablet
- Strength Formulation
- 0.25 mg Clonazepam + 10 mg Propranolol (Low Strength)
- Packaging Type
- Moisture-Resistant Blister Strips (10x10 / 20x10)
- Regulatory Category
- Narcotic Drug
- Marketing Division
- Blessme · Neuro & Psychiatric Products
- Manufacturing Standard
- WHO-GMP & ISO 9001:2015 Certified Clean-Room Compression
- Storage Condition
- Store below 25°C in a dry place. Protect from heat and moisture.
- Country of Origin
- India
Clinical & Commercial MonographClonazepam + Propranolol Tablet & DELOTRIL-PRO-LS
Clonazepam + Propranolol Tablet & DELOTRIL-PRO-LS
Complete Medical & Supply Guide
In-depth pharmacological evaluation of Clonazepam IP 0.25 mg + Propranolol HCl IP 10 mg tablets, marketed as DELOTRIL-PRO-LS by Blessme (Dellwich Lifescience LLP). Covers neuro-autonomic mechanisms, performance anxiety protocols, and B2B pharmaceutical supply across India.
What is DELOTRIL-PRO-LS (Clonazepam 0.25 mg + Propranolol 10 mg)?
DELOTRIL-PRO-LS is a fixed-dose oral neuropsychiatric tablet engineered to manage anxiety conditions where physical symptoms dominate. Cognitive fear surges trigger sympathetic outflow from the hypothalamus, producing adrenaline rushes that accelerate heart rate, cause tremors, and stimulate sweating.
When doctors and distributors look for Clonazepam Propranolol tablet or low strength somatic anxiety medicine, they require precise dose balancing that calms both mind and body without inducing day-time lethargy. DELOTRIL-PRO-LS achieves this through automated clean-room compression under WHO-GMP compliance.
Clinical Uses & Evidence-Based Indications
Evidence-based neuropsychiatric indications for DELOTRIL-PRO-LS include:
- Performance Anxiety & Stage Fright: Rapid elimination of voice tremor, rapid pulse, and cognitive fear before presentations.
- Somatic Anxiety Disorder: Chronic generalized worry characterized by cardiac and autonomic hyperarousal.
- Situational Panic Attacks: Abortive and preventative relief from stress-induced autonomic cascades.
- Stress-Induced Essential Tremor: Stabilizes hand and postural tremors worsened by emotional strain.
- Autonomic Hyperactivity: Restlessness, palpitations, and somatic tension under psychological pressure.
Neurochemical Mechanism of Action: Central & Peripheral Synergy
Clonazepam acts as a positive allosteric modulator on the GABAA receptor complex in the limbic cortex and amygdala, enhancing chloride ion conductance and dampening fear circuitry firing. At the 0.25 mg micro-dose, it delivers clean psychological calming without mental sluggishness.
Simultaneously, Propranolol competitively blocks peripheral beta-1 adrenergic receptors in the myocardium and beta-2 receptors in peripheral vascular and muscular tissues. This prevents adrenaline from inducing palpitations, tachycardia, and tremors. By eliminating physical alarm cues, the brain is not triggered into further panic, interrupting the vicious feedback loop.
Formulation Comparison: DELOTRIL-PRO-LS vs. DELOTRIL-PRO-0.25
Clinical criteria for selecting between the two strengths:
- DELOTRIL-PRO-LS (0.25 mg + 10 mg): Lower beta-blocker dose (10 mg) suitable for mild somatic panic, beta-blocker sensitive patients, and initial therapy.
- DELOTRIL-PRO-0.25 (0.25 mg + 20 mg): Higher beta-blocker dose (20 mg) for patients with prominent cardiovascular autonomic signs (resting tachycardia, bounding pulse).
- DELOTRIL-PRO-0.5 (0.5 mg + 20 mg): Full-strength central and peripheral formulation for severe panic disorder with agoraphobia.
Dosage Guidelines & Administration Method
DELOTRIL-PRO-LS must be taken strictly in accordance with medical advice:
- Situational Anxiety: Take one tablet 30 to 60 minutes before the stressful event with water.
- Maintenance Dosing: 1 tablet once or twice daily as prescribed by the treating psychiatrist.
- With or Without Food: Can be administered with meals to minimize potential mild gastrointestinal upset.
- Tapering Protocol: Gradual dose reduction is advised after continuous therapy to avoid rebound anxiety or tachycardia.
Critical Safety Warning - Schedule H Controlled Psychotropic Substance
DELOTRIL-PRO-LS contains Clonazepam, which has potential for dependence and habit formation with prolonged use. Propranolol is contraindicated in bronchial asthma, severe bradycardia, and high-degree heart block. Dispensed strictly against a valid medical prescription.
Quality & Production
Pharmaceutical Quality Assurance & Compliance
DELOTRIL-PRO-LS is manufactured in WHO-GMP certified facilities adhering to Schedule M protocols, ensuring micro-blend homogeneity and maximum packaging stability.
02 / PROTECTIVE PACKAGING
Moisture-Barrier Blister Foil
Sealed in tropicalized blister strips engineered to resist humidity, light exposure, and ambient temperature swings, preserving active potency across all Indian climate zones.
03 / PHARMACOPOEIA DOSSIERS
COA & Batch Testing Records
Every batch is backed by authenticated Certificates of Analysis (COA), disintegration profiles, assay validation data, and Material Safety Data Sheets for hospital audits.
04 / WHO-GMP COMPLIANCE
Schedule M Manufacturing
Produced in state-of-the-art accredited manufacturing units in Gujarat adhering to automated compression, online check-weighing, and Good Laboratory Practices (GLP).
Clinical Profile & Precautions
Approved Indications & Regulatory Guidelines
Prescribing guidance, contraindications, and drug interactions for Clonazepam + Propranolol tablets.
Prescription-Only Schedule H Medication Notice
DELOTRIL-PRO-LS is a Schedule H prescription drug. Not for OTC sale. Do not consume alcohol during therapy. Exercise caution when driving or operating machinery.
Clinical Indications Profile
Approved neurological and psychiatric indications for DELOTRIL-PRO-LS:
- Somatic Anxiety Disorder: Relief of chronic somatic hyperarousal and cardiac awareness.
- Performance Phobia: Situational stage fright, exam phobia, and public speaking panic.
- Episodic Autonomic Surges: Stress-induced palpitations, tremor, and perspiration.
- Essential Tremor: Relief of postural tremor exacerbated by anxiety.
Contraindications & Precautions
Key contraindications and monitoring requirements:
- Bronchial Asthma & COPD: Propranolol beta-2 blockade can trigger severe bronchospasm.
- Cardiovascular Impairments: Contraindicated in marked bradycardia, sick sinus syndrome, and AV block.
- Alcohol Prohibition: Dangerous synergism leading to severe hypotension and CNS depression.
- Pregnancy & Lactation: Avoid use unless explicitly advised by a specialist.
Manufacturing & Marketing
Dellwich Lifescience LLPBlessme · Neuro & Psychiatric Division
About Dellwich Lifescience
Trusted Neuro & Psychiatric Pharmaceutical Manufacturer in Ahmedabad, Gujarat
Dellwich Lifescience LLP is an established pharmaceutical company based in Science City, Ahmedabad, Gujarat, dedicated to advanced formulation technology, uncompromising quality assurance, and ethical healthcare supply. Through our specialized neurology division, Blessme, we manufacture and market superior neuro-psychiatric treatments, including DELOTRIL-PRO-LS (Clonazepam 0.25 mg + Propranolol 10 mg Tablets).
We support PCD pharma franchise partners, hospital supply chains, and contract manufacturing clients across India with guaranteed supply security, validated product dossiers, and prompt dispatch.
Commercial PartnershipsDELOTRIL-PRO-LS Supply &
DELOTRIL-PRO-LS Supply &
Pharmaceutical Distribution
Whether you are seeking DELOTRIL-PRO-LS for district monopoly PCD franchise distribution, third-party contract manufacturing, or hospital bulk procurement, Dellwich Lifescience LLP delivers dependable supply and competitive trade margins.
Exclusive Monopoly PCD Franchise
Secure district-level monopoly marketing rights for DELOTRIL-PRO-LS and the Blessme neuropsychiatry range with visual aids, product glossaries, and promotional input support.
Third-Party Contract Manufacturing
Turnkey manufacturing solutions for pharmaceutical marketing companies with flexible batch runs, rapid production turnaround, and full regulatory dossier support from Ahmedabad.
Hospital & Institutional Procurement
Direct bulk pharmaceutical supply agreements for multispecialty hospital chains, psychiatric nursing homes, and institutional medical tenders with prompt pan-India logistics.
Blessme · DELOTRIL-PRO-LS
Why Choose DELOTRIL-PRO-LS Tablets?
When sourcing Clonazepam Propranolol tablets in India, DELOTRIL-PRO-LS by Blessme provides exceptional clinical efficacy, reliable blister packaging, and comprehensive B2B franchise support.
WHO-GMP Certified Purity
Manufactured in accredited facilities using IP grade APIs, ensuring exact active content uniformity and fast disintegration.
High-Barrier Blister Packaging
Tamper-evident, moisture-resistant blister strips protect tablets from ambient humidity and transport friction.
Pan-India Dispatch from Ahmedabad
Direct factory dispatch with GST invoicing, verified batch COA, and dependable logistics coverage across all Indian states.
Monopoly PCD Franchise Rights
Exclusive district-level franchise rights for DELOTRIL-PRO-LS and the Blessme portfolio with promotional visual aids.
Comprehensive Regulatory Dossiers
Certificates of Analysis (COA), stability testing data, and MSDS readily available for institutional audits and tenders.
Direct Manufacturer Support
Direct access to Dellwich Lifescience product specialists for quick quotes, customized bulk orders, and customer assistance.
Common Questions
Frequently Asked Questions about DELOTRIL-PRO-LS
Authoritative answers to clinical, commercial, dosage, and regulatory questions regarding Clonazepam + Propranolol tablets.
What is DELOTRIL-PRO-LS and what are its active ingredients?
DELOTRIL-PRO-LS is an oral prescription tablet from the Blessme division of Dellwich Lifescience. It combines Clonazepam IP 0.25 mg (a high-potency benzodiazepine) with Propranolol Hydrochloride IP 10 mg (a non-selective beta blocker). The abbreviation 'LS' stands for Low Strength, designed to provide calming relief from physical and emotional anxiety symptoms with minimum sedation.
How does the combination of Clonazepam and Propranolol work?
DELOTRIL-PRO-LS works through dual complementary action: Clonazepam modulates central GABA_A receptors to enhance inhibitory chloride influx in the amygdala, producing limbic calmness. Simultaneously, Propranolol blocks peripheral beta-1 and beta-2 adrenergic receptors, directly preventing adrenaline-induced physical symptoms like palpitations, tachycardia, and hand tremors.
What is the difference between DELOTRIL-PRO-LS and DELOTRIL-PRO-0.25?
DELOTRIL-PRO-LS contains Clonazepam 0.25 mg combined with 10 mg of Propranolol, whereas DELOTRIL-PRO-0.25 contains Clonazepam 0.25 mg paired with 20 mg of Propranolol. The LS formulation is optimal for patients sensitive to beta-blockers, individuals requiring subtle autonomic buffering without blood pressure dips, or patients initiating therapy.
Is DELOTRIL-PRO-LS effective for performance anxiety and stage fright?
Yes. DELOTRIL-PRO-LS is widely prescribed by psychiatrists for performance anxiety, public speaking panic, and situational stress. The Propranolol component stops somatic tremors, voice quivering, and tachycardia, while low-dose Clonazepam quiets cognitive anticipatory panic without causing drowsiness.
When should DELOTRIL-PRO-LS be taken before an event?
For situational or performance anxiety, clinicians typically advise taking one tablet approximately 30 to 60 minutes prior to the stress-inducing event, strictly in accordance with psychiatric recommendations.
Can DELOTRIL-PRO-LS cause low blood pressure or bradycardia?
Because Propranolol is a beta-blocker, it naturally moderates heart rate and can slightly lower blood pressure. The 10 mg dose in DELOTRIL-PRO-LS has a gentle cardiovascular profile, but patients with pre-existing hypotension, sick sinus syndrome, or severe bradycardia must avoid its use.
Is DELOTRIL-PRO-LS suitable for asthmatic patients?
No. Non-selective beta blockers like Propranolol can block bronchial beta-2 receptors, potentially triggering bronchospasm. DELOTRIL-PRO-LS is contraindicated in patients with bronchial asthma or severe chronic obstructive pulmonary disease (COPD).
Can this medication be stopped abruptly?
If taken continuously for several weeks, DELOTRIL-PRO-LS must never be stopped abruptly. Gradual dose tapering under psychiatric supervision prevents rebound tachycardia, anxiety spikes, and autonomic withdrawal crises.
Can alcohol be consumed while taking DELOTRIL-PRO-LS?
No. Alcohol potentiates the central nervous system depressant effects of Clonazepam, causing severe sedation, impaired motor coordination, respiratory depression, and extreme hypotension. Alcohol consumption must be strictly avoided.
What packaging options are available for DELOTRIL-PRO-LS?
DELOTRIL-PRO-LS is packaged in high-grade 10x10 and 20x10 blister strips manufactured with moisture-barrier foils, ensuring extended shelf life and active ingredient potency.
What is the difference between DELOTRIL-PRO-LS and DELOTRIL-PRO-0.5?
DELOTRIL-PRO-LS contains Clonazepam 0.25 mg + Propranolol 10 mg (ideal for mild somatic anxiety and performance tremors). In contrast, DELOTRIL-PRO-0.5 contains Clonazepam 0.5 mg + Propranolol 20 mg (indicated for moderate-to-severe panic crises and intense cardiovascular hyperarousal).
How can I apply for PCD Pharma franchise rights for DELOTRIL-PRO-LS?
Pharmaceutical distributors, stockists, and medical representatives can submit an enquiry through our online form below or contact our neuropsychiatry franchise desk at +91 99099 31992 for monopoly district allocation.
Does Dellwich Lifescience offer third-party manufacturing for this tablet?
Yes. Dellwich Lifescience provides turnkey third-party manufacturing for Clonazepam + Propranolol combinations in various strengths with GMP certification, customized branding, and on-time shipment dispatch.
Where is Dellwich Lifescience headquartered?
Dellwich Lifescience LLP is headquartered in Ahmedabad, Gujarat, India — one of the nation's premier pharmaceutical hubs with rapid logistics connections across all Indian states.
Direct Pharmaceutical Enquiry
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Comprehensive Marketing, Visual Aids & Promotional Inputs
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