01 / DUAL ACTIVE ASSAY
Balanced Anxiolytic-Beta Blocker Ratio
Each tablet contains Clonazepam 0.25 mg and Propranolol 20 mg with precision content uniformity and consistent dissolution kinetics complying with Indian Pharmacopoeia standards.
Blessme · Anti-Panic & Somatic Anxiolytics
Clonazepam + Propranolol Tablets - DELOTRIL-PRO-0.25
DELOTRIL-PRO-0.25 is an advanced fixed-dose combination oral tablet uniting Clonazepam IP 0.25 mg with Propranolol Hydrochloride IP 20 mg by Blessme, the neurology and psychiatry division of Dellwich Lifescience LLP. Specifically designed to control somatic panic storms, public speaking phobias, and stress-induced tremors by combining central limbic calming with robust peripheral beta-adrenergic cardiac protection.
20 mg Beta-Blocker Shield
Schedule H Prescription
Pan-India Supply
Product SpecificationsAbout Clonazepam + Propranolol
About Clonazepam + Propranolol
(DELOTRIL-PRO-0.25)
Detailed pharmaceutical specifications, active API monograph compliance, balanced somatic synergy, and blister packaging details for DELOTRIL-PRO-0.25.
Blessme · Somatic Anxiolytic & Beta Blocker
Clonazepam + Propranolol - DELOTRIL-PRO-0.25
DELOTRIL-PRO-0.25 provides 0.25 mg Clonazepam paired with 20 mg Propranolol Hydrochloride. It provides complete protection against the physical sensations of panic (racing pulse, tremors, flushing) while keeping the mind alert and composed.
20 mg Propranolol Actively Halts Palpitations & Tremors 0.25 mg Clonazepam Quells Fear Without Heavy Sedation First-Line Choice for Severe Performance Anxiety Tropical Blister Foil Packing for Tropical Stability Strict Indian Pharmacopoeia Quality Standards
- Product Brand Name
- DELOTRIL-PRO-0.25
- Active Pharmaceutical Ingredients
- Clonazepam IP 0.25 mg + Propranolol HCl IP 20 mgVerified IP
- Therapeutic Class
- Neuropsychiatric Anxiolytic & Beta-Adrenergic Blocker
- Dosage Form
- Oral Solid Compressed Tablet
- Strength Formulation
- 0.25 mg Clonazepam + 20 mg Propranolol
- Packaging Type
- Moisture-Resistant Blister Strips (10x10 / 20x10)
- Regulatory Category
- Narcotic Drug
- Marketing Division
- Blessme · Neuro & Psychiatric Products
- Manufacturing Standard
- WHO-GMP & ISO 9001:2015 Certified Clean-Room Compression
- Storage Condition
- Store below 25°C in a dry place. Protect from heat and moisture.
- Country of Origin
- India
Clinical & Commercial MonographClonazepam + Propranolol Tablet & DELOTRIL-PRO-0.25
Clonazepam + Propranolol Tablet & DELOTRIL-PRO-0.25
Complete Medical & Supply Guide
In-depth pharmacological evaluation of Clonazepam IP 0.25 mg + Propranolol HCl IP 20 mg tablets, marketed as DELOTRIL-PRO-0.25 by Blessme (Dellwich Lifescience LLP). Covers somatic feedback loops, stage fright mitigation, and pharmaceutical supply across India.
What is DELOTRIL-PRO-0.25 (Clonazepam 0.25 mg + Propranolol 20 mg)?
DELOTRIL-PRO-0.25 is an optimized dual-action oral tablet that addresses anxiety through two distinct physiological pathways. While psychological anxiety originates in the limbic system, its physical symptoms (tachycardia, diaphoresis, hyperventilation, tremors) are executed through the sympathetic nervous system via beta-adrenergic receptors.
When clinicians search for Clonazepam Propranolol 0.25 20 tablet or tablet for stage fright and palpitations, they require proven content uniformity and reliable release kinetics. DELOTRIL-PRO-0.25 delivers these qualities through automated clean-room manufacturing under WHO-GMP compliance.
Clinical Uses & Evidence-Based Indications
Approved neurological and psychiatric indications for DELOTRIL-PRO-0.25 include:
- Social Phobia & Public Performance Panic: Prevents stage fright, vocal quivering, and tachycardia in auditions, speeches, and exams.
- Somatic Generalized Anxiety Disorder: Chronic anxiety dominated by visceral and cardiac symptoms.
- Acute Panic Attacks with Tachycardia: Rapid blunting of sympathetic cascades and acute emotional terror.
- Essential & Postural Tremor: Relief of stress-aggravated kinetic hand shaking.
- Cardiovascular Neurosis (Da Costa's Syndrome): Cardiac anxiety in patients with structurally normal hearts.
Neurochemical Mechanism of Action: Dual-Target Calming
Propranolol 20 mg competitively antagonizes beta-1 and beta-2 adrenergic receptors throughout the cardiovascular and musculoskeletal systems. This effectively prevents catecholamines (epinephrine and norepinephrine) from causing sinus tachycardia, systolic blood pressure spikes, and peripheral muscle tremors.
Simultaneously, Clonazepam 0.25 mg acts as a positive allosteric modulator on the GABAA receptor-chloride ion channel complex. It increases the frequency of channel openings, augmenting chloride influx and hyperpolarizing limbic neurons. By shutting off both the central fear alarm and peripheral bodily panic symptoms, DELOTRIL-PRO-0.25 delivers complete emotional composure.
Formulation Comparison: DELOTRIL-PRO-0.25 vs. DELOTRIL-PRO-0.5
Clinical criteria for selecting between the formulations:
- DELOTRIL-PRO-0.25 (0.25 mg + 20 mg): Lower Clonazepam dose minimizes daytime drowsiness, making it ideal for working professionals, presentations, and mild-to-moderate panic.
- DELOTRIL-PRO-0.5 (0.5 mg + 20 mg): Higher Clonazepam dose provides deeper central anxiolysis for patients with severe agoraphobia, intense panic crises, and psychiatric agitation.
- DELOTRIL-PRO-LS (0.25 mg + 10 mg): Lower beta-blocker strength for patients sensitive to hypotensive dips.
Dosage Guidelines & Administration Method
DELOTRIL-PRO-0.25 must be taken strictly in accordance with medical advice:
- Situational Anxiety: Take one tablet 45 to 60 minutes before the stressful event with water.
- Maintenance Dosing: 1 tablet once or twice daily as prescribed by the treating psychiatrist.
- With or Without Food: Can be administered with meals to minimize potential mild gastrointestinal upset.
- Gradual Tapering: If taken continuously for several weeks, taper slowly to prevent rebound tachycardia and withdrawal anxiety.
Critical Safety Warning - Schedule H Controlled Psychotropic Substance
DELOTRIL-PRO-0.25 contains Clonazepam, which carries potential for tolerance and habit formation with prolonged therapy. Contraindicated in patients with asthma, COPD, severe bradycardia, or high-degree AV block. Dispensed strictly against a valid medical prescription.
Quality & Production
Pharmaceutical Quality Assurance & Compliance
DELOTRIL-PRO-0.25 is manufactured in WHO-GMP certified facilities adhering to Schedule M protocols, ensuring micro-blend homogeneity and maximum packaging stability.
02 / PROTECTIVE PACKAGING
Moisture-Barrier Blister Foil
Sealed in tropicalized blister strips engineered to resist humidity, light exposure, and ambient temperature swings, preserving active potency across all Indian climate zones.
03 / PHARMACOPOEIA DOSSIERS
COA & Batch Testing Records
Every batch is backed by authenticated Certificates of Analysis (COA), disintegration profiles, assay validation data, and Material Safety Data Sheets for hospital audits.
04 / WHO-GMP COMPLIANCE
Schedule M Manufacturing
Produced in state-of-the-art accredited manufacturing units in Gujarat adhering to automated compression, online check-weighing, and Good Laboratory Practices (GLP).
Clinical Profile & Precautions
Approved Indications & Regulatory Guidelines
Prescribing guidance, contraindications, and drug interactions for Clonazepam 0.25 mg + Propranolol 20 mg tablets.
Prescription-Only Schedule H Medication Notice
DELOTRIL-PRO-0.25 is a Schedule H prescription drug. Not for OTC sale. Do not consume alcohol during therapy. Exercise caution when driving or operating machinery.
Clinical Indications Profile
Approved neurological and psychiatric indications for DELOTRIL-PRO-0.25:
- Somatic Panic Disorder: Relief of palpitations, chest tightness, and anticipatory fear.
- Performance Phobia: Situational stage fright, exam phobia, and public speaking panic.
- Episodic Autonomic Surges: Stress-induced palpitations, tremor, and perspiration.
- Essential Tremor: Relief of postural tremor exacerbated by anxiety.
Contraindications & Precautions
Key contraindications and monitoring requirements:
- Bronchial Asthma & COPD: Propranolol beta-2 blockade can trigger severe bronchospasm.
- Cardiovascular Impairments: Contraindicated in marked bradycardia, sick sinus syndrome, and AV block.
- Alcohol Prohibition: Dangerous synergism leading to severe hypotension and CNS depression.
- Diabetic Patients: May mask tachycardia associated with hypoglycemia.
Manufacturing & Marketing
Dellwich Lifescience LLPBlessme · Neuro & Psychiatric Division
About Dellwich Lifescience
Trusted Neuro & Psychiatric Pharmaceutical Manufacturer in Ahmedabad, Gujarat
Dellwich Lifescience LLP is an established pharmaceutical company based in Science City, Ahmedabad, Gujarat, dedicated to advanced formulation technology, uncompromising quality assurance, and ethical healthcare supply. Through our specialized neurology division, Blessme, we manufacture and market superior neuro-psychiatric treatments, including DELOTRIL-PRO-0.25 (Clonazepam 0.25 mg + Propranolol 20 mg Tablets).
We support PCD pharma franchise partners, hospital supply chains, and contract manufacturing clients across India with guaranteed supply security, validated product dossiers, and prompt dispatch.
Commercial PartnershipsDELOTRIL-PRO-0.25 Supply &
DELOTRIL-PRO-0.25 Supply &
Pharmaceutical Distribution
Whether you are seeking DELOTRIL-PRO-0.25 for district monopoly PCD franchise distribution, third-party contract manufacturing, or hospital bulk procurement, Dellwich Lifescience LLP delivers dependable supply and competitive trade margins.
Exclusive Monopoly PCD Franchise
Secure district-level monopoly marketing rights for DELOTRIL-PRO-0.25 and the Blessme neuropsychiatry range with visual aids, product glossaries, and promotional input support.
Third-Party Contract Manufacturing
Turnkey manufacturing solutions for pharmaceutical marketing companies with flexible batch runs, rapid production turnaround, and full regulatory dossier support from Ahmedabad.
Hospital & Institutional Procurement
Direct bulk pharmaceutical supply agreements for multispecialty hospital chains, psychiatric nursing homes, and institutional medical tenders with prompt pan-India logistics.
Blessme · DELOTRIL-PRO-0.25
Why Choose DELOTRIL-PRO-0.25 Tablets?
When sourcing Clonazepam Propranolol tablets in India, DELOTRIL-PRO-0.25 by Blessme provides exceptional clinical efficacy, reliable blister packaging, and comprehensive B2B franchise support.
WHO-GMP Certified Purity
Manufactured in accredited facilities using IP grade APIs, ensuring exact active content uniformity and fast disintegration.
High-Barrier Blister Packaging
Tamper-evident, moisture-resistant blister strips protect tablets from ambient humidity and transport friction.
Pan-India Dispatch from Ahmedabad
Direct factory dispatch with GST invoicing, verified batch COA, and dependable logistics coverage across all Indian states.
Monopoly PCD Franchise Rights
Exclusive district-level franchise rights for DELOTRIL-PRO-0.25 and the Blessme portfolio with promotional visual aids.
Comprehensive Regulatory Dossiers
Certificates of Analysis (COA), stability testing data, and MSDS readily available for institutional audits and tenders.
Direct Manufacturer Support
Direct access to Dellwich Lifescience product specialists for quick quotes, customized bulk orders, and customer assistance.
Common Questions
Frequently Asked Questions about DELOTRIL-PRO-0.25
Authoritative answers to clinical, commercial, dosage, and regulatory questions regarding Clonazepam + Propranolol tablets.
What is DELOTRIL-PRO-0.25 used for?
DELOTRIL-PRO-0.25 is prescribed for the treatment of anxiety disorders accompanied by marked physical symptoms such as palpitations, elevated pulse, hand tremors, and sweating. It is particularly effective for performance anxiety, social phobia, and acute situational stress.
What is the active composition of DELOTRIL-PRO-0.25?
Each compressed tablet contains Clonazepam IP 0.25 mg and Propranolol Hydrochloride IP 20 mg.
How does Propranolol 20 mg help in anxiety?
Propranolol is a beta-blocker that stops the autonomic response to stress by blocking adrenaline receptors. This prevents the heart from beating excessively fast, eliminates involuntary muscle shaking, and eliminates cold sweats, thereby removing the physical trigger of anxiety.
When should DELOTRIL-PRO-0.25 be consumed before a public event?
Clinicians usually recommend taking one tablet approximately 45 to 60 minutes before the stressful event, ensuring maximum plasma concentration of both active ingredients during peak exposure.
Will DELOTRIL-PRO-0.25 cause daytime sleepiness?
Because the Clonazepam dose is calibrated at 0.25 mg (half the standard 0.5 mg dose), most patients experience mental calmness without heavy sedation. However, individual sensitivity varies, and patients should avoid driving until their response is evaluated.
Who should not take DELOTRIL-PRO-0.25?
Patients with a history of asthma, COPD, AV heart block, severe low blood pressure, severe bradycardia, or known hypersensitivity to benzodiazepines or beta-blockers must not take this medication.
Can DELOTRIL-PRO-0.25 be stopped abruptly?
No. If taken regularly for more than 2 to 3 weeks, discontinuation should be gradual through tapering. Abrupt stoppage may trigger rebound tachycardia, hypertension, and withdrawal anxiety.
Is DELOTRIL-PRO-0.25 habit forming?
The Clonazepam component belongs to the benzodiazepine class and carries potential for psychological and physiological dependence when taken continuously over extended periods. It is designed for short-term symptomatic therapy or targeted situational usage.
Can patients with diabetes take DELOTRIL-PRO-0.25?
Propranolol may mask tachycardia, which is a key warning symptom of hypoglycemia in diabetic patients. Diabetic patients should use this medication with close blood glucose monitoring under physician guidance.
Can I drink alcohol while on DELOTRIL-PRO-0.25?
No. Alcohol interacts adversely with both Clonazepam and Propranolol, precipitating severe hypotension, profound drowsiness, respiratory depression, and dizziness.
What is the difference between DELOTRIL-PRO-0.25 and DELOTRIL-PRO-0.5?
DELOTRIL-PRO-0.25 contains 0.25 mg Clonazepam + 20 mg Propranolol, which is ideal for mild-to-moderate somatic panic and situational performance stress. DELOTRIL-PRO-0.5 contains 0.5 mg Clonazepam + 20 mg Propranolol, formulated for severe panic disorder and intense psychiatric agitation.
How is DELOTRIL-PRO-0.25 packed?
DELOTRIL-PRO-0.25 is supplied in premium 10x10 and 20x10 blister strips sealed with high-barrier foil to protect from heat and moisture degradation across all Indian climate conditions.
How do I get PCD monopoly franchise rights for this product?
You can send an enquiry using the form below or contact our neuropsychiatry business desk via WhatsApp at +91 99099 31992. We verify district availability and provide full monopoly agreement terms.
Where does Dellwich Lifescience manufacture DELOTRIL-PRO-0.25?
Manufactured in advanced WHO-GMP certified facilities located in Gujarat, adhering to Indian Pharmacopoeia standards and automated validation procedures.
Direct Pharmaceutical Enquiry
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Connect directly with Dellwich Lifescience LLP for trade pricing, district monopoly PCD rights, third-party manufacturing, or institutional hospital tender supplies.
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Comprehensive Marketing, Visual Aids & Promotional Inputs
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Get wholesale pricing, PCD franchise monopoly rights, and technical documentation for Clonazepam 0.25mg + Propranolol 20mg Tablets.