01 / DUAL ACTIVE ASSAY
Full-Strength Anxiolytic & Beta-Blocker
Each tablet contains Clonazepam 0.5 mg and Propranolol 20 mg with precision content uniformity and consistent dissolution kinetics complying with Indian Pharmacopoeia standards.
Blessme · Anti-Panic & Somatic Anxiolytics
Clonazepam + Propranolol Tablets - DELOTRIL-PRO-0.5
DELOTRIL-PRO-0.5 (also designated as DELOTRIL PRO) is a potent dual-action neuropsychiatric tablet uniting Clonazepam IP 0.5 mg with Propranolol Hydrochloride IP 20 mg by Blessme, Dellwich Lifescience LLP. Formulated for moderate-to-severe panic disorder, agoraphobia, and intense autonomic panic storms by extinguishing central fear cascades while eliminating adrenaline-driven tachycardia and tremors.
Full-Strength Dual Therapy
Schedule H Prescription
Pan-India Supply
Product SpecificationsAbout Clonazepam + Propranolol
About Clonazepam + Propranolol
(DELOTRIL-PRO-0.5)
Detailed pharmaceutical specifications, active API monograph compliance, full-strength somatic synergy, and 20x10 blister packaging details for DELOTRIL-PRO-0.5.
Blessme · Somatic Anxiolytic & Beta Blocker
Clonazepam + Propranolol - DELOTRIL-PRO-0.5
DELOTRIL-PRO-0.5 combines 0.5 mg Clonazepam with 20 mg Propranolol. Designed for moderate-to-severe panic disorder where profound psychological terror is coupled with terrifying physical palpitations, rapid pulse, and trembling.
0.5 mg Clonazepam Extinguishes Severe Panic & Dread 20 mg Propranolol Shields Against Tachycardia Storms Commercial 20x10 Blister Strip Format (MRP: ₹62.00) Primary Clinical Choice in Moderate-to-Severe Panic Disorder Strict Indian Pharmacopoeia Quality Standards
- Product Brand Name
- DELOTRIL-PRO-0.5 (DELOTRIL PRO)
- Active Pharmaceutical Ingredients
- Clonazepam IP 0.5 mg + Propranolol HCl IP 20 mgVerified IP
- Therapeutic Class
- Neuropsychiatric Anxiolytic & Beta-Adrenergic Blocker
- Dosage Form
- Oral Solid Compressed Tablet
- Strength Formulation
- 0.5 mg Clonazepam + 20 mg Propranolol
- Packaging Standard
- 20x10 Blister Strips (200 Tablets per Box)
- Indicative Catalog MRP
- ₹62.00 per Strip of 10 Tablets
- Regulatory Category
- Narcotic Drug
- Marketing Division
- Blessme · Neuro & Psychiatric Products
- Manufacturing Standard
- WHO-GMP & ISO 9001:2015 Certified Clean-Room Compression
- Storage Condition
- Store below 25°C in a dry place. Protect from heat and moisture.
- Country of Origin
- India
Clinical & Commercial MonographClonazepam + Propranolol Tablet & DELOTRIL-PRO-0.5
Clonazepam + Propranolol Tablet & DELOTRIL-PRO-0.5
Complete Medical & Supply Guide
In-depth pharmacological evaluation of Clonazepam IP 0.5 mg + Propranolol HCl IP 20 mg tablets, marketed as DELOTRIL-PRO-0.5 (DELOTRIL PRO) by Blessme (Dellwich Lifescience LLP). Covers somatic panic cascades, cardiac protection, and pharmaceutical supply across India.
What is DELOTRIL-PRO-0.5 (Clonazepam 0.5 mg + Propranolol 20 mg)?
DELOTRIL-PRO-0.5 is a full-strength dual-action neuropsychiatric tablet formulated to treat patients suffering from debilitating panic disorder and somatic distress. The combination addresses both ends of the panic reflex: the central nervous system trigger and the autonomic cardiovascular execution.
When doctors and hospitals search for Clonazepam Propranolol 0.5 20 tablet or medicine for severe panic attacks with tachycardia, they require proven content uniformity and reliable release kinetics. DELOTRIL-PRO-0.5 delivers these qualities through automated clean-room manufacturing under WHO-GMP compliance.
Clinical Uses & Evidence-Based Indications
Approved neurological and psychiatric indications for DELOTRIL-PRO-0.5 include:
- Moderate-to-Severe Panic Disorder: Rapid abortion of acute panic surges and long-term recurrence prevention.
- Panic with Agoraphobia: Calms anticipatory panic and somatic terror in open or public spaces.
- Refractory Generalized Anxiety Disorder: When somatic hyperarousal fails to respond to monotherapy.
- Post-Traumatic Stress Autonomic Surges: Manages acute adrenergic storms triggered by traumatic recall.
- Severe Essential Tremor with Anxiety: Substantial reduction in kinetic upper-limb tremulousness.
Neurochemical Mechanism of Action: Dual Panic Termination
Clonazepam 0.5 mg provides high occupancy of central GABAA receptor complexes in the amygdalo-hippocampal circuitry. By amplifying chloride ion conductance, it produces potent hyperpolarization that stops acute catastrophic thoughts and anticipatory dread.
Simultaneously, Propranolol 20 mg competitively occupies beta-1 adrenergic receptors on cardiac pacemakers and myocytes, preventing epinephrine from elevating heart rate and contractile force. This halts bounding tachycardia, cold sweats, and hyperventilation, eliminating the physical alarm signals that typically escalate panic into a clinical emergency.
Formulation Comparison: DELOTRIL-PRO-0.5 vs. DELOTRIL-PRO-0.25
Clinical criteria for selecting between the formulations:
- DELOTRIL-PRO-0.5 (0.5 mg + 20 mg): Higher central anxiolytic strength (0.5 mg Clonazepam) for severe panic disorder, intense agitation, and refractory anxiety.
- DELOTRIL-PRO-0.25 (0.25 mg + 20 mg): Lower Clonazepam dose for situational performance stress and social anxiety without sedation.
- DELOTRIL-PRO-LS (0.25 mg + 10 mg): Lower beta-blocker dose for patients sensitive to hypotensive dips.
Dosage Guidelines & Administration Method
DELOTRIL-PRO-0.5 must be taken strictly in accordance with medical advice:
- Panic Disorder Dose: Usually 1 tablet once or twice daily as determined by the psychiatrist.
- Administration: Swallow whole with water, preferably at regular intervals each day.
- With or Without Food: Can be taken with meals to minimize potential gastrointestinal discomfort.
- Gradual Tapering: If taken regularly for several weeks, taper slowly to prevent rebound tachycardia and withdrawal symptoms.
Critical Safety Warning - Schedule H Controlled Psychotropic Substance
DELOTRIL-PRO-0.5 contains Clonazepam, which carries potential for tolerance and habit formation with prolonged therapy. Contraindicated in patients with asthma, COPD, severe bradycardia, or high-degree AV block. Dispensed strictly against a valid medical prescription.
Quality & Production
Pharmaceutical Quality Assurance & Compliance
DELOTRIL-PRO-0.5 is manufactured in WHO-GMP certified facilities adhering to Schedule M protocols, ensuring micro-blend homogeneity and maximum packaging stability.
02 / PROTECTIVE PACKAGING
Commercial 20x10 Blister Strip
High-barrier blister packaging protects sensitive tablets from ambient moisture and light degradation, ensuring long-term shelf stability across tropical environments.
03 / PHARMACOPOEIA DOSSIERS
COA & Batch Testing Records
Every batch is backed by authenticated Certificates of Analysis (COA), disintegration profiles, assay validation data, and Material Safety Data Sheets for hospital audits.
04 / WHO-GMP COMPLIANCE
Schedule M Manufacturing
Produced in state-of-the-art accredited manufacturing units in Gujarat adhering to automated compression, online check-weighing, and Good Laboratory Practices (GLP).
Clinical Profile & Precautions
Approved Indications & Regulatory Guidelines
Prescribing guidance, contraindications, and drug interactions for Clonazepam 0.5 mg + Propranolol 20 mg tablets.
Prescription-Only Schedule H Medication Notice
DELOTRIL-PRO-0.5 is a Schedule H prescription drug. Not for OTC sale. Do not consume alcohol during therapy. Exercise caution when driving or operating machinery.
Clinical Indications Profile
Approved neurological and psychiatric indications for DELOTRIL-PRO-0.5:
- Severe Panic Disorder: Rapid abortion of panic surges and prevention of agoraphobia.
- Generalized Anxiety: Reduction of intense psychological fear and somatic muscle tension.
- Episodic Autonomic Surges: Stress-induced palpitations, tremor, and perspiration.
- Essential Tremor: Relief of postural tremor exacerbated by anxiety.
Contraindications & Precautions
Key contraindications and monitoring requirements:
- Bronchial Asthma & COPD: Propranolol beta-2 blockade can trigger severe bronchospasm.
- Cardiovascular Impairments: Contraindicated in marked bradycardia, sick sinus syndrome, and AV block.
- Alcohol Prohibition: Dangerous synergism leading to severe hypotension and CNS depression.
- Sedation Precautions: Drowsiness may impair motor skills during early therapy.
Manufacturing & Marketing
Dellwich Lifescience LLPBlessme · Neuro & Psychiatric Division
About Dellwich Lifescience
Trusted Neuro & Psychiatric Pharmaceutical Manufacturer in Ahmedabad, Gujarat
Dellwich Lifescience LLP is an established pharmaceutical company based in Science City, Ahmedabad, Gujarat, dedicated to advanced formulation technology, uncompromising quality assurance, and ethical healthcare supply. Through our specialized neurology division, Blessme, we manufacture and market superior neuro-psychiatric treatments, including DELOTRIL-PRO-0.5 (Clonazepam 0.5 mg + Propranolol 20 mg Tablets).
We support PCD pharma franchise partners, hospital supply chains, and contract manufacturing clients across India with guaranteed supply security, validated product dossiers, and prompt dispatch.
Commercial PartnershipsDELOTRIL-PRO-0.5 Supply &
DELOTRIL-PRO-0.5 Supply &
Pharmaceutical Distribution
Whether you are seeking DELOTRIL-PRO-0.5 for district monopoly PCD franchise distribution, third-party contract manufacturing, or hospital bulk procurement, Dellwich Lifescience LLP delivers dependable supply and competitive trade margins.
Exclusive Monopoly PCD Franchise
Secure district-level monopoly marketing rights for DELOTRIL-PRO-0.5 and the Blessme neuropsychiatry range with visual aids, product glossaries, and promotional input support.
Third-Party Contract Manufacturing
Turnkey manufacturing solutions for pharmaceutical marketing companies with flexible batch runs, rapid production turnaround, and full regulatory dossier support from Ahmedabad.
Hospital & Institutional Procurement
Direct bulk pharmaceutical supply agreements for multispecialty hospital chains, psychiatric nursing homes, and institutional medical tenders with prompt pan-India logistics.
Blessme · DELOTRIL-PRO-0.5
Why Choose DELOTRIL-PRO-0.5 Tablets?
When sourcing Clonazepam Propranolol tablets in India, DELOTRIL-PRO-0.5 by Blessme provides exceptional clinical efficacy, reliable 20x10 blister packaging, and comprehensive B2B franchise support.
WHO-GMP Certified Purity
Manufactured in accredited facilities using IP grade APIs, ensuring exact active content uniformity and fast disintegration.
High-Barrier 20x10 Blister Pack
Tamper-evident, moisture-resistant blister strips protect tablets from ambient humidity and transport friction.
Pan-India Dispatch from Ahmedabad
Direct factory dispatch with GST invoicing, verified batch COA, and dependable logistics coverage across all Indian states.
Monopoly PCD Franchise Rights
Exclusive district-level franchise rights for DELOTRIL-PRO-0.5 and the Blessme portfolio with promotional visual aids.
Comprehensive Regulatory Dossiers
Certificates of Analysis (COA), stability testing data, and MSDS readily available for institutional audits and tenders.
Direct Manufacturer Support
Direct access to Dellwich Lifescience product specialists for quick quotes, customized bulk orders, and customer assistance.
Common Questions
Frequently Asked Questions about DELOTRIL-PRO-0.5
Authoritative answers to clinical, commercial, dosage, and regulatory questions regarding Clonazepam + Propranolol tablets.
What is DELOTRIL-PRO-0.5 and what does it contain?
DELOTRIL-PRO-0.5 is a fixed-dose combination oral tablet manufactured under the Blessme neuropsychiatry division of Dellwich Lifescience. It contains Clonazepam IP 0.5 mg (a high-potency benzodiazepine anxiolytic) and Propranolol Hydrochloride IP 20 mg (a non-selective beta-blocker).
When is DELOTRIL-PRO-0.5 preferred over DELOTRIL-PRO-0.25?
DELOTRIL-PRO-0.5 is preferred when the patient experiences moderate-to-severe panic attacks, debilitating psychological anxiety, or agoraphobia requiring full 0.5 mg Clonazepam central fear reduction alongside the 20 mg Propranolol somatic cardiac control. DELOTRIL-PRO-0.25 is reserved for milder situational panic or when minimal sedation is desired.
How quickly does DELOTRIL-PRO-0.5 relieve symptoms?
The Propranolol component begins moderating heart rate and tremors within 30 to 60 minutes. Clonazepam exerts marked central calming and panic relief within 45 to 60 minutes, with peak therapeutic effect reached within 1 to 2 hours post-dose.
What is the standard packaging and MRP for DELOTRIL-PRO-0.5?
DELOTRIL-PRO-0.5 is packed in 20x10 blister strips (200 tablets per box) with an indicative catalog MRP of ₹62.00 per strip of 10 tablets, offering an affordable, high-quality option for long-term patient compliance.
Can DELOTRIL-PRO-0.5 cause drowsiness or dizziness?
Yes. Due to the 0.5 mg Clonazepam content, mild-to-moderate sedation, drowsiness, and lightheadedness can occur, particularly during initial days of therapy. Patients should avoid driving, operating heavy machinery, or engaging in hazardous tasks until tolerance develops.
What happens if a patient stops DELOTRIL-PRO-0.5 abruptly?
Abrupt discontinuation after continuous therapy can cause severe rebound anxiety, insomnia, tremors, and rebound tachycardia due to unmasked beta-adrenergic receptors and benzodiazepine withdrawal. Discontinuation must always follow a supervised tapering protocol.
Is this medicine safe in asthma patients?
No. Propranolol is a non-selective beta-blocker that blocks beta-2 receptors in the lungs, which can precipitate bronchospasm in asthmatic or COPD patients. It is strictly contraindicated in this patient population.
Can DELOTRIL-PRO-0.5 be taken with food?
Yes. DELOTRIL-PRO-0.5 can be taken with or without food. Taking it with meals may reduce potential mild gastrointestinal upset. Consistent timing each day is recommended.
Can this medicine be taken during pregnancy?
Both Clonazepam and Propranolol cross the placenta and carry potential risks to the developing fetus. DELOTRIL-PRO-0.5 should not be used in pregnancy unless deemed essential by a specialist physician.
Can I consume alcohol while taking DELOTRIL-PRO-0.5?
Alcohol is strictly prohibited. Combining alcohol with Clonazepam significantly increases the risk of severe central nervous system depression, respiratory arrest, profound hypotension, and coma.
What is the difference between DELOTRIL-PRO-0.5 and DELOTRIL-0.5 MD?
DELOTRIL-0.5 MD contains solely Clonazepam 0.5 mg in a fast-dissolving mouth dissolving tablet form. DELOTRIL-PRO-0.5 contains Clonazepam 0.5 mg combined with 20 mg Propranolol HCl, providing dual central and cardiovascular autonomic coverage.
How can distributors apply for PCD franchise monopoly?
Pharma stockists and distributors can complete the enquiry form below or contact our business development executive directly on WhatsApp at +91 99099 31992 to secure exclusive district marketing rights.
What is the minimum order quantity (MOQ) for third-party manufacturing?
We offer flexible MOQ options tailored to brand requirements with complete testing, artwork assistance, packaging design, and timely dispatch from our Gujarat facility.
Where is Dellwich Lifescience based?
Dellwich Lifescience LLP is located on Science City Road, Ahmedabad, Gujarat, India, with an established distribution network spanning all states across India.
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