01 / DUAL AXIS SYNERGY
Central & Peripheral Action
Simultaneous GABA_A receptor modulation via Alprazolam and beta-adrenergic blockade via Propranolol eliminates both psychic fear and physical tremors.
Blessme · Anxiolytics & Migraine
Propranolol + Alprazolam Tablets - MIGABET-PLUS
MIGABET-PLUS is a synergistic neuropsychiatric formulation combining Propranolol Hydrochloride IP 20 mg with Alprazolam IP 0.25 mg by Blessme, Dellwich Lifescience LLP. Specifically formulated for patients suffering from generalized anxiety disorder with pronounced autonomic manifestations, situational performance anxiety, panic attacks with palpitations, and migraine prophylaxis complicated by stress.
Central + Peripheral Synergy
Narcotic / Schedule H
Pan-India Supply
Product SpecificationsAbout Propranolol + Alprazolam
About Propranolol + Alprazolam
(MIGABET-PLUS)
Comprehensive pharmaceutical specifications, active API monograph compliance, dual receptor pharmacology, and 4x5x10 blister packaging details for MIGABET-PLUS.
Blessme · Anxiolytic & Anti-Migraine
Propranolol + Alprazolam - MIGABET-PLUS
MIGABET-PLUS unites 20 mg Propranolol with 0.25 mg Alprazolam. Formulated to provide rapid relief from both the emotional symptoms of anxiety (fear, worry) and the distressing physical symptoms (tachycardia, trembling, sweating).
20 mg Propranolol Blocks Peripheral Somatic Tremors & Palpitations0.25 mg Alprazolam Calms Central Psychic Anxiety & Panic Migraine Prophylaxis with Concomitant Stress Suppression 4x5x10 Blister Strip Format for Tropical Protection Strict Indian Pharmacopoeia Quality Standards
- Product Brand Name
- MIGABET-PLUS
- Active Pharmaceutical Ingredients
- Propranolol Hydrochloride IP 20 mg + Alprazolam IP 0.25 mgVerified IP
- Therapeutic Class
- Peripheral-Central Anxiolytic & Anti-Migraine Combination (Beta-Blocker & Benzodiazepine)
- Dosage Form
- Oral Solid Compressed Tablet
- Strength Formulation
- 20 mg Propranolol + 0.25 mg Alprazolam
- Packaging Standard
- 4x5x10 Blister Strips (200 Tablets per Box)
- Regulatory Category
- Narcotic Drug
- Marketing Division
- Blessme · Neuro & Psychiatric Products
- Manufacturing Standard
- WHO-GMP & ISO 9001:2015 Certified Clean-Room Compression
- Storage Condition
- Store below 25°C in a dry place. Protect from light and moisture.
- Country of Origin
- India
Clinical & Commercial MonographPropranolol + Alprazolam Tablet & MIGABET-PLUS
Propranolol + Alprazolam Tablet & MIGABET-PLUS
Complete Medical & Supply Guide
In-depth pharmacological evaluation of Propranolol 20 mg + Alprazolam 0.25 mg tablets, marketed as MIGABET-PLUS by Blessme (Dellwich Lifescience LLP). Covers adrenergic-GABAergic synergy, migraine prevention, and pharmaceutical franchise availability across India.
What is MIGABET-PLUS (Propranolol 20 mg + Alprazolam 0.25 mg)?
MIGABET-PLUS is a dual-mechanism oral formulation uniting a non-selective beta-adrenergic antagonist (Propranolol 20 mg) with a high-affinity positive allosteric GABA_A modulator (Alprazolam 0.25 mg).
Anxiety frequently manifests as a vicious cycle: mental worry triggers peripheral adrenaline release, causing palpitations and trembling, which in turn amplifies psychic terror. MIGABET-PLUS breaks this feedback loop at both ends—Alprazolam quiets the mind while Propranolol shields the body from autonomic storm.
Clinical Uses & Evidence-Based Indications
Approved neurological and psychiatric indications for MIGABET-PLUS include:
- Anxiety with Somatic Hyperarousal: Relieves chest pounding, tachycardia, and muscular tremors.
- Situational & Performance Anxiety: Prevents stage fright and acute public-speaking panic attacks.
- Panic Disorder Comorbid with Somatic Symptoms: Halts acute panic surges and cardiovascular agitation.
- Migraine Prophylaxis with Stress: Stabilizes cranial vasculature and reduces stress-triggered headache frequency.
- Essential Tremor Associated with Anxiety: Suppresses adrenaline-induced postural hand shaking.
Neurochemical Mechanism of Action: Dual Adrenergic & GABAergic Synergy
Alprazolam 0.25 mg acts centrally on GABAA receptor-chloride channels in the amygdala, cerebral cortex, and hippocampus. By enhancing inhibitory GABA neurotransmission, it produces rapid tranquility, diminishes anticipatory dread, and relieves emotional tension.
Concurrently, Propranolol 20 mg is a lipophilic non-selective beta-1 and beta-2 adrenergic antagonist that crosses the blood-brain barrier. In the periphery, it blocks beta-1 receptors in cardiac tissue to lower heart rate and myocardial contractility, preventing tachycardia and palpitations. It blocks beta-2 receptors in skeletal muscle to suppress hand tremors and reduces cranial vasodilation, providing robust prophylaxis against vascular migraine attacks.
MIGABET-PLUS vs. Conventional Anxiolytics
Advantages of the Propranolol-Alprazolam combination:
- Complete Symptom Relief: Benzodiazepine monotherapy often fails to control heart pounding and tremors; MIGABET-PLUS addresses both.
- Lower Benzodiazepine Dose: Incorporating 20 mg Propranolol allows a micro-dose of Alprazolam (0.25 mg), minimizing sedation and dependence liability.
- Vascular Stability: Provides prophylactic migraine protection alongside anxiety control.
Dosage Guidelines & Administration Method
MIGABET-PLUS must be taken strictly in accordance with medical advice:
- Anxiety Dosage: Typically 1 tablet twice daily, or 1 tablet taken 1 hour prior to acute anxiety-provoking situations.
- Migraine Prophylaxis: 1 tablet once or twice daily as prescribed by the neurologist.
- Take with Water: Swallow whole; do not chew or crush.
- Supervised Tapering: Discontinue gradually under medical supervision to avoid rebound anxiety and tachycardia.
Critical Safety Warning - Schedule H / Narcotic Controlled Substance
MIGABET-PLUS contains Alprazolam, which carries potential for dependence and habit formation with prolonged therapy. Contraindicated in bronchial asthma, severe COPD, sinus bradycardia, and cardiogenic shock. Do not consume alcohol during therapy. Dispensed strictly against a valid medical prescription.
Quality & Production
Pharmaceutical Quality Assurance & Compliance
MIGABET-PLUS is manufactured in WHO-GMP certified facilities adhering to Schedule M protocols, ensuring micro-blend homogeneity, exact active content, and superior packaging stability.
02 / PROTECTIVE PACKAGING
High-Barrier 4x5x10 Blister
Tropicalized 4x5x10 blister strips protect sensitive active APIs from moisture ingress and photodegradation, maintaining 36-month stability across all Indian zones.
03 / PHARMACOPOEIA DOSSIERS
COA & Batch Testing Records
Every batch is verified through authenticated Certificates of Analysis (COA), HPLC active assay validation, and dissolution profiles complying with IP standards.
04 / WHO-GMP COMPLIANCE
Schedule M Manufacturing
Produced in state-of-the-art cleanroom manufacturing units in Gujarat adhering to automated compression, online check-weighing, and Good Laboratory Practices (GLP).
Clinical Profile & Precautions
Approved Indications & Regulatory Guidelines
Prescribing guidance, contraindications, and drug interactions for Propranolol 20 mg + Alprazolam 0.25 mg tablets.
Prescription-Only Schedule H / Narcotic Medication Notice
MIGABET-PLUS is a Schedule H / Narcotic prescription drug. Not for OTC sale. Do not consume alcohol during therapy. Exercise caution when driving or operating machinery.
Clinical Indications Profile
Approved neurological and psychiatric indications for MIGABET-PLUS:
- Somatic Anxiety States: Reduces palpitation dread, autonomic tremors, and tachycardia.
- Performance / Situational Panic: Provides rapid control of stage fright and situational trembling.
- Stress-Induced Migraine Prophylaxis: Lowers the frequency and severity of vascular headaches.
- Essential Tremor: Attenuates adrenaline-aggravated hand shaking.
Contraindications & Precautions
Key contraindications and monitoring requirements:
- Bronchial Asthma & COPD: Contraindicated due to the risk of bronchospasm.
- Bradycardia & Heart Block: Do not use in patients with resting heart rate below 50 bpm or AV block.
- Alcohol Prohibition: Concurrent alcohol intake causes dangerous additive hypotension and CNS depression.
- Gradual Discontinuation: Taper slowly under physician direction to prevent rebound tachycardia and anxiety.
Manufacturing & Marketing
Dellwich Lifescience LLPBlessme · Neuro & Psychiatric Division
About Dellwich Lifescience
Trusted Neuro & Psychiatric Pharmaceutical Manufacturer in Ahmedabad, Gujarat
Dellwich Lifescience LLP is an established pharmaceutical company based in Science City, Ahmedabad, Gujarat, dedicated to advanced formulation technology, uncompromising quality assurance, and ethical healthcare supply. Through our specialized neurology division, Blessme, we manufacture and market superior neuro-psychiatric treatments, including MIGABET-PLUS (Propranolol 20 mg + Alprazolam 0.25 mg Tablets).
We support PCD pharma franchise partners, hospital supply chains, and contract manufacturing clients across India with guaranteed supply security, validated product dossiers, and prompt dispatch.
Commercial PartnershipsMIGABET-PLUS Supply &
MIGABET-PLUS Supply &
Pharmaceutical Distribution
Whether you are seeking MIGABET-PLUS for district monopoly PCD franchise distribution, third-party contract manufacturing, or hospital bulk procurement, Dellwich Lifescience LLP delivers dependable supply and competitive trade margins.
Exclusive Monopoly PCD Franchise
Secure district-level monopoly marketing rights for MIGABET-PLUS and the complete Blessme neuropsychiatry range with visual aids, product glossaries, and promotional input support.
Third-Party Contract Manufacturing
Turnkey manufacturing solutions for pharmaceutical marketing companies with flexible batch runs, rapid production turnaround, and full regulatory dossier support from Ahmedabad.
Hospital & Institutional Procurement
Direct bulk pharmaceutical supply agreements for multispecialty hospital chains, psychiatric nursing homes, and institutional medical tenders with prompt pan-India logistics.
Blessme · MIGABET-PLUS
Why Choose MIGABET-PLUS Tablets?
When sourcing Propranolol Alprazolam tablets in India, MIGABET-PLUS by Blessme provides exceptional clinical efficacy, reliable blister packaging, and comprehensive B2B franchise support.
WHO-GMP Certified Purity
Manufactured in accredited facilities using IP grade active APIs, ensuring exact active content uniformity and fast dissolution.
High-Barrier Blister Packaging
Tamper-evident, moisture-resistant blister strips protect tablets from ambient humidity and transport friction.
Pan-India Dispatch from Ahmedabad
Direct factory dispatch with GST invoicing, verified batch COA, and dependable logistics coverage across all Indian states.
Monopoly PCD Franchise Rights
Exclusive district-level franchise rights for MIGABET-PLUS and the Blessme portfolio with promotional visual aids.
Comprehensive Regulatory Dossiers
Certificates of Analysis (COA), stability testing data, and MSDS readily available for institutional audits and tenders.
Direct Manufacturer Support
Direct access to Dellwich Lifescience product specialists for quick quotes, customized bulk orders, and customer assistance.
Common Questions
Frequently Asked Questions about MIGABET-PLUS
Authoritative answers to clinical, commercial, dosage, and regulatory questions regarding Propranolol + Alprazolam tablets.
What is MIGABET-PLUS and what does it contain?
MIGABET-PLUS is an oral prescription tablet from the Blessme division of Dellwich Lifescience. It contains Propranolol Hydrochloride IP 20 mg and Alprazolam IP 0.25 mg, formulated to treat acute anxiety states with prominent autonomic symptoms (palpitations, tremors, tachycardia) and for migraine prophylaxis associated with stress.
How does the combination of Propranolol and Alprazolam work?
Alprazolam 0.25 mg acts centrally on GABA_A receptors to quench psychic fear, worrying thoughts, and panic. Simultaneously, Propranolol 20 mg blocks peripheral beta-adrenergic receptors, stopping the physiological adrenaline surge that causes rapid heart rate, chest pounding, sweating, and hand shaking.
What conditions are treated with MIGABET-PLUS?
MIGABET-PLUS is prescribed for Generalized Anxiety Disorder with somatic symptoms, situational/performance anxiety (stage fright), panic attacks with cardiac symptoms, tremor suppression, and migraine headache prophylaxis in patients with comorbid anxiety.
How quickly does MIGABET-PLUS start working?
Both active ingredients are rapidly absorbed. Alprazolam achieves peak central anxiolysis within 1 to 2 hours, while Propranolol provides noticeable reduction in heart rate and trembling within 60 to 90 minutes.
Can patients with asthma or low heart rate take MIGABET-PLUS?
No. Propranolol is contraindicated in patients with bronchial asthma, severe COPD, sinus bradycardia (heart rate below 50 bpm), second- or third-degree heart block, or cardiogenic shock, as it can cause bronchospasm and further lower heart rate.
Can MIGABET-PLUS cause daytime drowsiness?
Yes. Due to Alprazolam's sedative properties and Propranolol's blood pressure-lowering effect, mild drowsiness, fatigue, or dizziness can occur. Patients should avoid driving or operating machinery until their individual tolerance is established.
Can I drink alcohol while taking MIGABET-PLUS?
Alcohol is strictly prohibited. Combining alcohol with Alprazolam and Propranolol causes dangerous additive central nervous system depression, excessive hypotension, and profound sedation.
Is MIGABET-PLUS habit-forming?
The Alprazolam component carries risk of tolerance and psychological or physical dependence when taken continuously over extended periods. Clinicians typically prescribe it for short durations or on an as-needed basis.
Can MIGABET-PLUS be stopped abruptly?
No. Abrupt stoppage can lead to severe rebound anxiety, insomnia, and withdrawal symptoms from Alprazolam, as well as rebound tachycardia or blood pressure spikes from sudden beta-blocker cessation. A gradual tapering schedule is essential.
Can pregnant women take MIGABET-PLUS?
MIGABET-PLUS is contraindicated during pregnancy unless specifically evaluated by a medical specialist, as both Alprazolam and Propranolol can cross the placenta and pose risks to the developing fetus.
How is MIGABET-PLUS packaged?
MIGABET-PLUS is supplied in 4x5x10 blister strips (200 tablets per box) manufactured with tropicalized high-barrier foil to guarantee extended shelf life across all Indian climate conditions.
How can distributors apply for PCD franchise monopoly for MIGABET-PLUS?
Pharmaceutical distributors and stockists can submit an enquiry through our online form below or contact our neuropsychiatry franchise desk at +91 99099 31992 for monopoly territory allocation.
Does Dellwich Lifescience offer third-party manufacturing for MIGABET-PLUS?
Yes. Dellwich Lifescience provides turnkey contract manufacturing for Propranolol + Alprazolam tablets with WHO-GMP certification, customized branding, and fast dispatch from Ahmedabad.
Where is Dellwich Lifescience headquartered?
Dellwich Lifescience LLP is headquartered on Science City Road, Ahmedabad, Gujarat, India, with rapid nationwide logistics connections.
Direct Pharmaceutical Enquiry
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Comprehensive Marketing, Visual Aids & Promotional Inputs
Quick Assistance & Orders
Enquire About MIGABET-PLUS
Get wholesale pricing, PCD franchise monopoly rights, and technical documentation for Propranolol 20 mg + Alprazolam 0.25 mg Tablets.